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Cox, Brian, Hutson, Julie L, Keeling, Suzanne E, Kirk, Barrie E, Srikantha, Anton R P and Watson, Nigel S (1994) The squalestatins: potent inhibitors of squalene synthase, 3-hydroxymethyl derivatives. Bioorganic and Medicinal Chemistry Letters, 4 (16). pp. 1931-1936. ISSN 0960-894X
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Official URL: http://dx.doi.org/10.1016/S0960-894X(01)80537-0
Abstract
A series of 3-hydroxymethyl derivatives of squalestatin 1 was prepared as inhibitors of squalene synthase. Potent in vitro inhibitory activity is retained in those analogues which possess C-6 and C-1 substituents analogous to those found in 1.
Item Type: | Article |
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Schools and Departments: | School of Life Sciences > Chemistry |
Subjects: | Q Science > QD Chemistry |
Depositing User: | Tom Gittoes |
Date Deposited: | 14 Jan 2015 09:21 |
Last Modified: | 14 Jan 2015 09:21 |
URI: | http://sro.sussex.ac.uk/id/eprint/52119 |