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The squalestatins: potent inhibitors of squalene synthase, 3-hydroxymethyl derivatives
journal contribution
posted on 2023-06-08, 19:32 authored by Brian Cox, Julie L Hutson, Suzanne E Keeling, Barrie E Kirk, Anton R P Srikantha, Nigel S WatsonA series of 3-hydroxymethyl derivatives of squalestatin 1 was prepared as inhibitors of squalene synthase. Potent in vitro inhibitory activity is retained in those analogues which possess C-6 and C-1 substituents analogous to those found in 1.
History
Publication status
- Published
Journal
Bioorganic and Medicinal Chemistry LettersISSN
0960-894XPublisher
ElsevierExternal DOI
Issue
16Volume
4Page range
1931-1936Department affiliated with
- Chemistry Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2015-01-14Usage metrics
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