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Cox, Brian, Morley, Nicolas, Procopiou, Panayiotis A, Sharratt, Peter J, Watson, Nigel S and Wild, Deborah (2000) The squalestatins: tricyclic 3,4-β-lactone and 3,4-oxetane systems. Tetrahedron Letters, 41 (39). pp. 7547-7550. ISSN 0040-4039
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Official URL: http://dx.doi.org/10.1016/S0040-4039(00)01286-7
Abstract
Squalestatin 3,4-β-lactone-4,5-dimethyl ester (8) was reductively ring-opened to yield squalestatin 3-hydroxymethyl-4,5-dimethyl ester (6) using mild reducing conditions (sodium borohydride). Similarly, squalestatin 3,4-oxetane-4,5-dimethyl ester (10) was found to ring-open to 3-iodomethyl squalestatin (15) under the conditions used to cleave the methyl ester functions (lithium iodide/2,4,6-trimethylpyridine).
Item Type: | Article |
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Schools and Departments: | School of Life Sciences > Chemistry |
Subjects: | Q Science > QD Chemistry |
Depositing User: | Tom Gittoes |
Date Deposited: | 13 Jan 2015 12:04 |
Last Modified: | 13 Jan 2015 12:04 |
URI: | http://sro.sussex.ac.uk/id/eprint/52062 |