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2-Cycloalkyl phenoxyacetic acid CRTh2 receptor antagonists

journal contribution
posted on 2023-06-08, 19:29 authored by David A Sandham, Clive Aldcroft, Urs Baettig, Lucy Barker, David Beer, Gurdip Bhalay, Zarin Brown, Gerald Dubois, David Budd, Louise Bidlake, Emma Campbell, Brian Cox, Brian Everatt, David Harrison, Catherine J Leblanc, Jodie Manini, Rachael Profit, Rowan Stringer, Katy S Thompson, Katharine L Turner, Morris F Tweed, Christopher Walker, Simon J Watson, Steven Whitebread, Jennifer Willis, Gareth Williams, Caroline Wilson
High throughput screening identified a phenoxyacetic acid scaffold as a novel CRTh2 receptor antagonist chemotype, which could be optimised to furnish a compound with functional potency for inhibition of human eosinophil shape change and oral bioavailability in the rat.

History

Publication status

  • Published

Journal

Bioorganic and Medicinal Chemistry Letters

ISSN

0960-894X

Publisher

Elsevier

Issue

15

Volume

17

Page range

4347-4350

Department affiliated with

  • Chemistry Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2015-01-13

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