University of Sussex
Browse

File(s) not publicly available

Preparation and characterization of solid dispersions of piroxicam with hydrophilic carriers

journal contribution
posted on 2023-06-08, 19:18 authored by Hadi Valizadeh, Parvin Zakeri-Milani, Mohammad Barzegar-Jalali, Ghobad Mohammadi, Mohammad-Ali Danesh-Bahreini, Khosro Adibkia, Ali Nokhodchi
The objective of this study was to improve the dissolution rate of a poor water soluble drug, piroxicam, by solid dispersion technique. Solid dispersions were prepared by three different methods depending on the type of carrier. The dissolution rate of piroxicam was markedly increased in solid dispersion of myrj 52, Eudragit E100 and mannitol. Solubility studies revealed a marked increase in the solubility of piroxicam with an increase in myrj 52 and Eudragit E100 concentrations. Data from the X-ray diffraction and FT-IR spectroscopy showed that piroxicam was amorphous in the solid dispersions prepared with dextrin and Eudragit E100.

History

Publication status

  • Published

Journal

Drug Development and Industrial Pharmacy

ISSN

0363-9045

Publisher

Informa Healthcare

Issue

1

Volume

33

Page range

45-56

Department affiliated with

  • Chemistry Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2015-01-06

Usage metrics

    University of Sussex (Publications)

    Categories

    No categories selected

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC