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Homeostatic regulation of meiotic DSB formation by ATM/ATR

journal contribution
posted on 2023-06-08, 19:15 authored by Timothy Cooper, Kayleigh Wardell, Valerie Garcia, Matt NealeMatt Neale
Ataxia-telangiectasia mutated (ATM) and RAD3-related (ATR) are widely known as being central players in the mitotic DNA damage response (DDR), mounting responses to DNA double-strand breaks (DSBs) and single-stranded DNA (ssDNA) respectively. The DDR signalling cascade couples cell cycle control to damage-sensing and repair processes in order to prevent untimely cell cycle progression while damage still persists [1]. Both ATM/ATR are, however, also emerging as essential factors in the process of meiosis; a specialised cell cycle programme responsible for the formation of haploid gametes via two sequential nuclear divisions. Central to achieving accurate meiotic chromosome segregation is the introduction of numerous DSBs spread across the genome by the evolutionarily conserved enzyme, Spo11. This review seeks to explore and address how cells utilise ATM/ATR pathways to regulate Spo11-DSB formation, establish DSB homeostasis and ensure meiosis is completed unperturbed.

Funding

Biochemical reconstitution of DNA repair reactions on intact chromatin; G0986; EUROPEAN UNION; 311336

History

Publication status

  • Published

File Version

  • Published version

Journal

Experimental Cell Research

ISSN

1090-2422

Publisher

Elsevier

Issue

1

Volume

329

Page range

124-131

Department affiliated with

  • Sussex Centre for Genome Damage Stability Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2014-12-09

First Compliant Deposit (FCD) Date

2014-12-09

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