University of Sussex
Browse
ejn12754_(2).pdf (550.87 kB)

Spatial and temporal distribution of visual information coding in lateral prefrontal cortex

Download (550.87 kB)
journal contribution
posted on 2023-06-08, 18:42 authored by Mikiko Kadohisa, Makoto Kusunoki, Philippe Petrov, Natasha SigalaNatasha Sigala, Mark Buckley, David Gaffan, John Duncan
Prefrontal neurons code many kinds of behaviourally relevant visual information. In behaving monkeys, we used a cued target detection task to address coding of objects, behavioural categories and spatial locations, examining the temporal evolution of neural activity across dorsal and ventral regions of the lateral prefrontal cortex (encompassing parts of areas 9, 46, 45A and 8A), and across the two cerebral hemispheres. Within each hemisphere there was little evidence for regional specialisation, with neurons in dorsal and ventral regions showing closely similar patterns of selectivity for objects, categories and locations. For a stimulus in either visual field, however, there was a strong and temporally specific difference in response in the two cerebral hemispheres. In the first part of the visual response (50–250 ms from stimulus onset), processing in each hemisphere was largely restricted to contralateral stimuli, with strong responses to such stimuli, and selectivity for both object and category. Later (300–500 ms), responses to ipsilateral stimuli also appeared, many cells now responding more strongly to ipsilateral than to contralateral stimuli, and many showing selectivity for category. Activity on error trials showed that late activity in both hemispheres reflected the animal's final decision. As information is processed towards a behavioural decision, its encoding spreads to encompass large, bilateral regions of prefrontal cortex.

History

Publication status

  • Published

File Version

  • Published version

Journal

European Journal of Neuroscience

ISSN

0953-816X

Publisher

Blackwell Publishing

Issue

1

Volume

41

Page range

89-96

Department affiliated with

  • BSMS Neuroscience Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2014-10-16

First Open Access (FOA) Date

2014-10-16

First Compliant Deposit (FCD) Date

2014-10-15

Usage metrics

    University of Sussex (Publications)

    Categories

    No categories selected

    Licence

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC