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An imbalance in serum concentrations of inflammatory and anti-inflammatory cytokines in hypertension
journal contribution
posted on 2023-06-08, 18:36 authored by Seyed Reza Mirhafez, Mohsen Mohebati, Mahboobeh Feiz Disfani, Maryam Saberi Karimian, Mahmoud Ebrahimi, Amir Avan, Saled Eslami, Alireza Pasdar, Hassan Rooki, Habibollah Esmaeili, Gordon FernsGordon Ferns, Majid Ghayour-MobarhanHypertension is an important risk factor for cardiovascular disease and there is increasing evidence that inflammation and abnormal immune responses are involved in the pathogenesis of hypertension. However, the data on the association between specific cytokine concentrations and hypertension are inconsistent. We have evaluated the association between 12 cytokines/growth factors and the presence of different degrees of hypertension, comparing these concentrations to values in a healthy group of subjects. The concentrations of interleukin (IL)-1a, -1ß, -2, -4, -6, -8, -10, tumor necrosis factor (TNF-a), interferon-? (IFN-?), monocyte chemoattractant protein (MCP-1), epidermal growth factor, and vascular endothelial growth factor were measured in 155 hypertensive patients and 148 healthy subjects, using EV-3513 cytokine biochip arrays, a competitive chemiluminescence immunoassay. Univariate and multivariate analyses were used to evaluate the association of specific cytokines and growth factors with systolic blood pressure (SBP) and diastolic blood pressure (DBP). Hypertensive subjects had higher serum concentrations of IL-1a, -2, -8, vascular endothelial growth factor, IFN-?, TNF-a, MCP-1, and epidermal growth factor; and lower concentrations of anti-inflammatory cytokine, IL-10 (P < .05), compared with the healthy individuals. The serum concentrations of IL-4, -6, and -1ß did not differ between the hypertensive subjects and control group. Univariate and multivariate analyses revealed that IL-1a and IFN-? were independent predictors of a high SBP, while IFN-?, IL-1a, TNF-a, and MCP-1 remained statistically significant for DBP after correction for age, gender, Body mass index, smoking, fasting blood glucose, and triglycerides. There was a significant association between the concentrations of several cytokines and hypertension. These associations may either be related to common underlying factors that cause hypertension and may also be proinflammatory or because these inflammatory cytokines might directly be involved in the etiology of hypertension.
History
Publication status
- Published
Journal
Journal of the American Society of HypertensionISSN
1933-1711Publisher
ElsevierExternal DOI
Issue
9Volume
8Page range
614-623Department affiliated with
- Division of Medical Education Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2014-10-06Usage metrics
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