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Multifunctional 8-hydroxyquinoline-appended cyclodextrins as new inhibitors of metal-induced protein aggregation

journal contribution
posted on 2023-06-08, 18:34 authored by Valentina Oliveri, Francesco Attanasio, Attanasio Puglisi, John SpencerJohn Spencer, Carmelo Sgarlata, Graziella Vecchio
Mounting evidence suggests a pivotal role of metal imbalances in protein misfolding and amyloid diseases. As such, metal ions represent a promising therapeutic target. In this context, the synthesis of chelators that also contain complementary functionalities to combat the multifactorial nature of neurodegenerative diseases is a highly topical issue. We report two new 8-hydroxyquinoline-appended cyclodextrins and highlight their multifunctional properties, including their CuII and ZnII binding abilities, and capacity to act as antioxidants and metal-induced antiaggregants. In particular, the latter property has been applied in the development of an effective assay that exploits the formation of amyloid fibrils when b-lactoglobulin A is heated in the presence of metal ions.

History

Publication status

  • Published

Journal

Chemistry - A European Journal

ISSN

0947-6539

Publisher

Wiley-VCH Verlag Berlin

Issue

29

Volume

20

Page range

8954-8964

Department affiliated with

  • Chemistry Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2014-09-30

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    University of Sussex (Publications)

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