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Synthesis of oxindole-based bioorganometallic kinase inhibitors incorporating one or more ferrocene groups
journal contribution
posted on 2023-06-08, 18:34 authored by Jahangir Amin, Irina Chuckowree, Minghua Wang, Graham J Tizzard, Simon J Coles, John SpencerJohn SpencerA series of oxindole-containing ferrocenes has been synthesized, studied in the solid state by X-ray crystallography, and tested for in vitro kinase inhibition. Many compounds show low or submicromolar activities against DYRK isoforms and VEGFR2, which in certain cases have been rationalized by molecular docking studies.
History
Publication status
- Published
Journal
OrganometallicsISSN
0276-7333Publisher
American Chemical SocietyExternal DOI
Issue
20Volume
32Page range
5818-5825Department affiliated with
- Chemistry Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2014-09-30Usage metrics
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