Ridi, A, Scalas, E and Gliozzi, A (2000) Noise measurements in bilayer lipid membranes during electroporation. The European physical journal. E, Soft matter, 2 (2). pp. 161-168. ISSN 1292-8941

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Abstract

A study of voltage fluctuations in bilayer lipid membranes during electroporation and under current-clamp conditions is presented. Qualitative considerations based on the electroporation theory are used in order to explain the phenomenon on long time scale. Indeed, the current-clamp condition induces a feedback mechanism on the pore formation and therefore on the macroscopic conductance. Voltage fluctuations can thus be recorded. These fluctuations are nonstationary long-living and have a flicker power spectrum over nearly four decades of frequency between about 10-2 and 102Hz. The study of the fluctuations in the time domain has been performed by introducing an electrical model of the system formed by the membrane and the circuit under current-clamp configuration. The analysis of the time series gives a characteristic time of 100ms for the circuitry response to the fragments of electroporation signals with characteristic times faster than 100ms. During electroporation, the response to an external periodic stimulus in the frequency range 10-1-10Hz shows that the system behaves linearly, even if voltage fluctuations are present.

Item Type:	Article
Schools and Departments:	School of Mathematical and Physical Sciences > Mathematics
Subjects:	Q Science > QC Physics > QC0170 Atomic physics. Constitution and properties of matter Including molecular physics, relativity, quantum theory, and solid state physics
Depositing User:	Enrico Scalas
Date Deposited:	02 Oct 2014 10:52
Last Modified:	02 Oct 2014 10:52
URI:	http://sro.sussex.ac.uk/id/eprint/50300

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