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Interaction of dipyridamole with phospholipid monolayers at the air-water interface: surface pressure and grazing incidence X-ray diffraction studies

journal contribution
posted on 2023-06-08, 18:27 authored by H Haas, W Caetano, G P Borissevitch, M Tabak, M I Mosquera Sanchez, O N Oliveira, Enrico Scalas, M Goldman
Incorporation of dipyridamole (DIP) in Langmuir monolayers of the zwitterionic phospholipid dipalmitoylphosphatidylcholine (DPPC) has been investigated using surface pressure isotherm and grazing incidence X-ray diffraction (GIXD) measurements. An expansion in the pressure–area isotherms of the DPPC monolayer was observed, which was maximum in the liquid-expanded (LE) to liquid-condensed (LC) transition region and at a DIP concentration of 2 mol%. Accordingly, the GIXD measurements indicated an expansion of the 2D lattice in the LC phase up to a surface pressure of ca. 30 mN/m. A condensation effect on the DPPC packing for high DIP concentrations, as previously suggested, can be ruled out.

History

Publication status

  • Published

Journal

Chemical Physics Letters

ISSN

0009-2614

Publisher

Elsevier

Issue

5-6

Volume

335

Page range

510-516

Department affiliated with

  • Mathematics Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2014-10-01

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