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The impact of strain diversity and mixed infections on the evolution of resistance to Bacillus thuringiensis
journal contribution
posted on 2023-06-08, 18:12 authored by Ben Raymond, Denis J Wright, Neil CrickmoreNeil Crickmore, Michael B BonsallPesticide mixtures can reduce the rate at which insects evolve pesticide resistance. However, with live biopesticides such as the naturally abundant pathogen Bacillus thuringiensis (Bt), a range of additional biological considerations might affect the evolution of resistance. These can include ecological interactions in mixed infections, the different rates of transmission post-application and the impact of the native biodiversity on the frequency of mixed infections. Using multi-generation selection experiments, we tested how applications of single and mixed strains of Bt from diverse sources (natural isolates and biopesticides) affected the evolution of resistance in the diamondback moth, Plutella xylostella, to a focal strain. There was no significant difference in the rate of evolution of resistance between single and mixed-strain applications although the latter did result in lower insect populations. The relative survivorship of Bt-resistant genotypes was higher in the mixed-strain treatment, in part owing to elevated mortality of susceptible larvae in mixtures. Resistance evolved more quickly with treatments that contained natural isolates, and biological differences in transmission rate may have contributed to this. Our data indicate that the use of mixtures can have unexpected consequences on the fitness of resistant and susceptible insects.
History
Publication status
- Published
Journal
Proceedings of the Royal Society B: Biological SciencesISSN
0962-8452Publisher
Royal Society PublishingExternal DOI
Issue
1769Volume
280Page range
20131497Department affiliated with
- Biochemistry Publications
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- No
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- Yes
Legacy Posted Date
2014-09-05Usage metrics
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