Starting and stopping SUMOylation. What regulates the regulator?

Watts, Felicity Z (2013) Starting and stopping SUMOylation. What regulates the regulator? Chromosoma, 122 (6). pp. 451-463. ISSN 0009-5915

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A large number of proteins are modified posttranslationally
by the ubiquitin-like protein (Ubl) SUMO.
This process, known as sumoylation, regulates the function,
localisation and activity of target proteins as part of normal
cellular metabolism, e.g., during development, and through
the cell cycle, as well as in response to a range of stresses. In
order to be effective, the sumoylation pathway itself must also
be regulated. This review describes how the SUMOylation
process is regulated. In particular, regulation of the SUMO
conjugation and deconjugation machinery at the level of transcription
and by post-translational modifications is discussed.

Item Type: Article
Schools and Departments: School of Life Sciences > Sussex Centre for Genome Damage and Stability
Subjects: Q Science > QD Chemistry > QD0241 Organic chemistry > QD0415 Biochemistry
Depositing User: Gee Wheatley
Date Deposited: 07 Aug 2014 10:48
Last Modified: 03 Jul 2019 01:02

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