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Starting and stopping SUMOylation. What regulates the regulator?
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posted on 2023-06-08, 18:02 authored by Felicity WattsA large number of proteins are modified posttranslationally by the ubiquitin-like protein (Ubl) SUMO. This process, known as sumoylation, regulates the function, localisation and activity of target proteins as part of normal cellular metabolism, e.g., during development, and through the cell cycle, as well as in response to a range of stresses. In order to be effective, the sumoylation pathway itself must also be regulated. This review describes how the SUMOylation process is regulated. In particular, regulation of the SUMO conjugation and deconjugation machinery at the level of transcription and by post-translational modifications is discussed.
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Publication status
- Published
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- Published version
Journal
ChromosomaISSN
0009-5915Publisher
SpringerExternal DOI
Issue
6Volume
122Page range
451-463Department affiliated with
- Sussex Centre for Genome Damage Stability Publications
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- No
Peer reviewed?
- Yes
Legacy Posted Date
2014-08-07First Compliant Deposit (FCD) Date
2014-08-07Usage metrics
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