Gu_and_Kanai_(2014).pdf (377.9 kB)
What contributes to individual differences in brain structure?
journal contribution
posted on 2023-06-08, 17:36 authored by Jenny Gu, Ryota KanaiIndividual differences in adult human brain structure have been found to reveal a great deal of information about variability in behaviors, cognitive abilities and mental and physical health. Driven by such evidence, what contributes to individual variation in brain structure has gained accelerated attention as a research question. Findings thus far appear to support the notion that an individual’s brain architecture is determined largely by genetic and environmental influences. This review aims to evaluate the empirical literature on whether and how genes and the environment contribute to individual differences in brain structure. It first considers how genetic and environmental effects may separately contribute to brain morphology, by examining evidence from twin, genome-wide association, cross-sectional and longitudinal studies. Next, evidence for the influence of the complex interplay between genetic and environmental factors, characterized as gene-environment interactions and correlations, is reviewed. In evaluating the extant literature, this review will conclude that both genetic and environmental factors play critical roles in contributing to individual variability in brain structure.
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Publication status
- Published
File Version
- Published version
Journal
Frontiers in Human NeuroscienceISSN
1662-5161Publisher
FrontiersExternal DOI
Issue
262Volume
8Page range
1-6Department affiliated with
- Psychology Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2014-06-11First Open Access (FOA) Date
2014-06-11First Compliant Deposit (FCD) Date
2014-06-11Usage metrics
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