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Clinical and pharmacogenomic implications of genetic variation in an Ethiopian population
journal contribution
posted on 2023-06-08, 17:34 authored by Fasil Tekola-Ayele, Adebowale Adeyemo, Abraham Assefa, Elena Hailu, Christopher Finan, Gail DaveyGail Davey, Charles Rotimi, Melanie NewportMelanie NewportAfrica is home to genetically diverse human populations. We compared the genetic structure of the Wolaita ethnic population from southern Ethiopia (WETH, n=120) with HapMap populations using genome-wide variants. We investigated allele frequencies of 443 clinically and pharmacogenomically relevant genetic variants in WETH compared to HapMap populations. We found that WETH were genetically most similar to the Kenya Maasai and least similar to the Japanese in HapMap. Variant alleles associated with increased risk of adverse reactions to drugs used for treating tuberculosis (rs1799929 and rs1495741 in NAT2), thromboembolism (rs7294, rs9923231 and rs9934438 in VKORC1), and HIV/AIDS and solid tumors (rs2242046 in SLC28A1) had significantly higher frequency in WETH compared to African ancestry HapMap populations. Our results illustrate that clinically relevant pharmacogenomic loci display allele frequency differences among African populations; therefore, drug dosage guidelines for diseases of global health relevance should be validated in genetically diverse African populations.
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Publication status
- Published
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- Accepted version
Journal
Pharmacogenomics JournalISSN
1470-269XPublisher
NatureExternal DOI
Issue
1Volume
15Page range
101-108Department affiliated with
- Clinical and Experimental Medicine Publications
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- No
Peer reviewed?
- Yes
Legacy Posted Date
2014-06-09First Compliant Deposit (FCD) Date
2014-06-09Usage metrics
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