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Newborns develop a Th1-type immune response to Mycobacterium bovis bacillus Calmette-Guérin vaccination

journal contribution
posted on 2023-06-08, 17:10 authored by Arnaud Marchant, Tessa Goetghebuer, Martin O Ota, Ingrid Wolfe, Serign J Ceesay, Donat De Groote, Tumani Corrah, Steve Bennett, Jeremy Wheeler, Kris Huygen, Peter Aaby, Keith P J W McAdam, Melanie NewportMelanie Newport
Data obtained in animals indicate that neonatal immune responses are biased toward Th2. This could reduce the efficacy of vaccines against viral and mycobacterial diseases. The ability of human newborns to develop a Th1 immune response upon immunization has not been studied. Since the vaccine Mycobacterium bovis bacillus Calmette-Guérin (BCG) triggers a Th1-type response in adults, we investigated whether it induces a similar response in newborns and whether age at vaccination influences immunogenicity. We found that BCG vaccination at birth induces a memory Th1-type response of similar magnitude to that when given later in life. This study demonstrates that human newborns can be immunized against pathogens controlled by a Th1 immune response.

History

Publication status

  • Published

Journal

Journal of Immunology

ISSN

0022-1767

Publisher

American Association of Immunologists

Issue

4

Volume

163

Page range

2249-2255

Department affiliated with

  • Global Health and Infection Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2014-05-08

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