File(s) not publicly available
Newborns develop a Th1-type immune response to Mycobacterium bovis bacillus Calmette-Guérin vaccination
journal contribution
posted on 2023-06-08, 17:10 authored by Arnaud Marchant, Tessa Goetghebuer, Martin O Ota, Ingrid Wolfe, Serign J Ceesay, Donat De Groote, Tumani Corrah, Steve Bennett, Jeremy Wheeler, Kris Huygen, Peter Aaby, Keith P J W McAdam, Melanie NewportMelanie NewportData obtained in animals indicate that neonatal immune responses are biased toward Th2. This could reduce the efficacy of vaccines against viral and mycobacterial diseases. The ability of human newborns to develop a Th1 immune response upon immunization has not been studied. Since the vaccine Mycobacterium bovis bacillus Calmette-Guérin (BCG) triggers a Th1-type response in adults, we investigated whether it induces a similar response in newborns and whether age at vaccination influences immunogenicity. We found that BCG vaccination at birth induces a memory Th1-type response of similar magnitude to that when given later in life. This study demonstrates that human newborns can be immunized against pathogens controlled by a Th1 immune response.
History
Publication status
- Published
Journal
Journal of ImmunologyISSN
0022-1767Publisher
American Association of ImmunologistsIssue
4Volume
163Page range
2249-2255Department affiliated with
- Global Health and Infection Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2014-05-08Usage metrics
Categories
No categories selectedKeywords
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC