Analysis of IL10 haplotypic associations with severe malaria

Wilson, J N, Rockett, K, Jallow, M, Pinder, M, Sisay-Joof, F, Newport, M, Newton, J and Kwiatkowski, D (2005) Analysis of IL10 haplotypic associations with severe malaria. Genes and Immunity, 6 (6). pp. 462-466. ISSN 1466-4879

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We investigated the association between severe malaria and genetic variation of IL10 in Gambian children, as several lines of evidence indicate that IL10 is protective against severe malaria and that IL10 production is genetically determined. We began by identifying five informative SNPs in the Gambian population that were genotyped in a combined case-control and intrafamilial study including 654 cases of severe malaria, 579 sets of parents and 459 ethnically matched controls. No significant associations were identified with individual SNPs. One haplotype of frequency 0.11 was strongly associated with protection against severe malaria in the case-control analysis (odds ratio 0.52, P=0.00002), but the transmission disequilibrium test in families showed no significant effect. These findings raise the question of whether IL10 associations with severe malaria might be confounded by foetal survival rates or other sources of transmission bias.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Primary Care and Public Health
Brighton and Sussex Medical School > Global Health and Infection
Subjects: R Medicine > RC Internal medicine > RC0251 Constitutional diseases (General)
Depositing User: Pam Thompson
Date Deposited: 09 May 2014 13:27
Last Modified: 21 Sep 2017 13:33
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