File(s) not publicly available
Predominant influence of environmental determinants on the persistence and avidity maturation of antibody responses to vaccines in infants
journal contribution
posted on 2023-06-08, 17:09 authored by Arnaud Marchant, Maria Pihlgren, Tessa Goetghebuer, Helen A Weiss, Martin O C Ota, Susana E Schlegel-Hauter, Hilton Whittle, Paul-Henri Lambert, Melanie NewportMelanie Newport, Claire-Anne SiegristBACKGROUND Immune responses are complex traits influenced by genetic and environmental factors. We previously reported that genetic factors control early antibody responses to vaccines in Gambian infants. For the present study, we evaluated the determinants of the memory phase of immunoglobulin G (IgG) responses. METHODS Antibody responses to tetanus toxoid (TT), measles vaccines, and environmental antigens (total IgG levels) were measured in 210 Gambian twin pairs recruited at birth. Intrapair correlations for monozygous and dizygous pairs were compared to estimate the environmental and genetic components of variations in response. RESULTS In contrast to antibody responses measured in infants at age 5 months, 1 month after immunization, no significant contribution of genetic factors to anti-TT antibody and total IgG levels was detected at age 12 months. Genetic factors controlled measles antibody responses in 12-month-old infants, which indicates that the increasing influence of environmental determinants on anti-TT responses was not related to the older age of the children but, rather, to the time elapsed since immunization. Environmental factors also predominantly controlled affinity maturation and the production of high-avidity antibodies to TT. CONCLUSIONS Genetic determinants control the early phase of the vaccine antibody response in Gambian infants, whereas environmental determinants predominantly influence antibody persistence and avidity maturation.
History
Publication status
- Published
Journal
Journal of Infectious DiseasesISSN
0022-1899Publisher
Oxford University PressPublisher URL
Issue
11Volume
193Page range
1598-605Department affiliated with
- Global Health and Infection Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2014-05-09Usage metrics
Categories
No categories selectedKeywords
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC