Emerging role of endosomal toll-like receptors in rheumatoid arthritis

Thwaites, Ryan, Chamberlain, Giselle and Sacre, Sandra (2014) Emerging role of endosomal toll-like receptors in rheumatoid arthritis. Frontiers in Immunology, 5. pp. 1-8. ISSN 1664-3224

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Toll-like receptors (TLRs) and their downstream signaling pathways have been comprehensively characterized in innate immunity. In addition to this function, these receptors have also been suggested to be involved in the pathogenesis of many autoimmune diseases, including rheumatoid arthritis (RA). Murine in vivo models and human in vitro tissue models of RA have provided a wealth of information on the potential activity of TLRs and components of the downstream signaling pathways. Whilst most early work investigated the cell surface TLRs, more recently the focus has moved to the endosomal TLRs 3, 7, 8, and 9. These receptors recognize self and foreign double-stranded RNA and single-stranded RNA and DNA. The development of therapeutics to inhibit the endosomal TLRs or components of their signaling cascades may represent a way to target inflammation upstream of cytokine production. This may allow for greater specificity than existing therapies including cytokine blockade. Here, we review the current information suggesting a role for the endosomal TLRs in RA pathogenesis and the efforts to target these receptors therapeutically.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Clinical and Experimental Medicine
Subjects: R Medicine > RB Pathology > RB127 Manifestations of disease
Depositing User: Sandra Sacre
Date Deposited: 06 May 2014 08:21
Last Modified: 02 Jul 2019 17:46
URI: http://sro.sussex.ac.uk/id/eprint/48345

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