University of Sussex
Browse
The_role_of_the_humoral_immune_response_to_Clostridium_difficile.pdf (148.32 kB)

The role of the humoral immune response to Clostridium difficile toxins A and B in susceptibility to C. difficile infection: a case-control study

Download (148.32 kB)
journal contribution
posted on 2023-06-08, 17:08 authored by J Islam, A L Taylor, K Rao, G Huffnagle, V B Young, C Rajkumar, J Cohen, P Papatheodorou, D M Aronoff, Martin LlewelynMartin Llewelyn
Antibody levels to Clostridium difficile toxin A (TcdA), but not toxin B (TcdB), have been found to determine risk of C. difficile infection (CDI). Historically, TcdA was thought to be the key virulence factor; however the importance of TcdB in disease is now established. We re-evaluated the role of antibodies to TcdA and TcdB in determining patient susceptibility to CDI in two separate patient cohorts. In contrast to earlier studies, we find that CDI patients have lower pre-existing IgA titres to TcdB, but not TcdA, when compared to control patients. Our findings suggest that mucosal immunity to TcdB may be important in the early stages of infection and identifies a possible target for preventing CDI progression.

History

Publication status

  • Published

File Version

  • Accepted version

Journal

Anaerobe

ISSN

1095-8274

Publisher

Elsevier Masson

Volume

27

Page range

82-86

Department affiliated with

  • Global Health and Infection Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2014-05-02

First Open Access (FOA) Date

2016-03-22

First Compliant Deposit (FCD) Date

2016-08-17

Usage metrics

    University of Sussex (Publications)

    Categories

    No categories selected

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC