The_role_of_the_humoral_immune_response_to_Clostridium_difficile.pdf (148.32 kB)
The role of the humoral immune response to Clostridium difficile toxins A and B in susceptibility to C. difficile infection: a case-control study
journal contribution
posted on 2023-06-08, 17:08 authored by J Islam, A L Taylor, K Rao, G Huffnagle, V B Young, C Rajkumar, J Cohen, P Papatheodorou, D M Aronoff, Martin LlewelynMartin LlewelynAntibody levels to Clostridium difficile toxin A (TcdA), but not toxin B (TcdB), have been found to determine risk of C. difficile infection (CDI). Historically, TcdA was thought to be the key virulence factor; however the importance of TcdB in disease is now established. We re-evaluated the role of antibodies to TcdA and TcdB in determining patient susceptibility to CDI in two separate patient cohorts. In contrast to earlier studies, we find that CDI patients have lower pre-existing IgA titres to TcdB, but not TcdA, when compared to control patients. Our findings suggest that mucosal immunity to TcdB may be important in the early stages of infection and identifies a possible target for preventing CDI progression.
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Publication status
- Published
File Version
- Accepted version
Journal
AnaerobeISSN
1095-8274Publisher
Elsevier MassonExternal DOI
Volume
27Page range
82-86Department affiliated with
- Global Health and Infection Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2014-05-02First Open Access (FOA) Date
2016-03-22First Compliant Deposit (FCD) Date
2016-08-17Usage metrics
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