Trullas, Joan Carles, Mocroft, Amanda, Cofan, Federico, Tourret, Jérome, Moreno, Asunción, Bagnis, Corinne Isnard, Fux, Christoph Andreas, Katlama, Christine, Reiss, Peter, Lundgren, Jens, Gatell, Jose Maria, Kirk, Ole, Miró, Jose M, the EuroSIDA Investigators, and FIsher, Martin (2010) Dialysis and renal transplantation in HIV-infected patients: a European survey. JAIDS Journal of Acquired Immune Deficiency Syndromes, 55 (5). pp. 582-589. ISSN 1944-7884

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Abstract

OBJECTIVES

To determine prevalence and characteristics of end-stage renal diseases (ESRD) [dialysis and renal transplantation (RT)] among European HIV-infected patients.

METHODS

Cross-sectional multicenter survey of EuroSIDA clinics during 2008.

RESULTS

Prevalence of ESRD was 0.5%. Of 122 patients with ESRD 96 were on dialysis and 26 had received a RT. Median age was 47 years, 73% were males and 43% were black. Median duration of HIV infection was 11 years. Thirty-three percent had prior AIDS; 91% were receiving antiretrovirals; and 88% had undetectable viral load. Median CD4(+)T-cell count was 341 cells per cubic millimetre; 20.5% had hepatitis C coinfection. Most frequent causes of ESRD were HIV-associated nephropathy (46%) and other glomerulonephritis (28%). Hemodialysis (93%) was the most common dialysis modality; 34% of patients were on the RT waiting list. A poor HIV control was the reason for exclusion from RT waiting list in 22.4% of cases. All the RT recipients were all alive at the time of the survey. Acute rejection was reported in 8 patients (30%). Functioning graft was present in 21 (80%).

CONCLUSIONS

This is the first multinational cross-sectional study of ESRD among European HIV population. Low prevalence of ESRD was found. Two-thirds of patients were excluded from RT for non-HIV/AIDS-related pathologies. Most patients had a functioning graft despite a high acute rejection rate.

Item Type:	Article
Additional Information:	Martin Fisher is not a lead author but one of the EuroSIDA Investigators
Schools and Departments:	Brighton and Sussex Medical School > Brighton and Sussex Medical School
Subjects:	R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine > RA0643 Communicable diseases and public health > RA0644 Individual diseases or groups of diseases, A-Z > RA0644.A25 AIDS. HIV infections
Depositing User:	Ellen Thomas
Date Deposited:	07 Apr 2014 12:58
Last Modified:	07 Apr 2014 12:59
URI:	http://sro.sussex.ac.uk/id/eprint/47549

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