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Memantine affects cognitive flexibility in the Morris water maze

journal contribution
posted on 2023-06-08, 16:23 authored by Bechara J Saab, Ruxandra Luca, Wing B Yuen, Adam M P Saab, John C Roder
Alzheimer's disease (AD) is multi-factorial mental disorder characterized by a copious array of congruent features cumulating in disrupted memory and dysthymia. Though the mechanism remains elusive, the highly unspecific pharmaceutical, memantine, provides modest benefits for patients with moderate-to-severe AD. A greater understanding of how memantine affects cognitive function promises to facilitate the search for better therapeutics. We therefore examined cognitive flexibility of mice following 5 and 10 mg/kg memantine administration using a platform re-location water maze. Strikingly, subjects receiving memantine demonstrated memory impairment relative to controls when re-trained off drug, revealing a novel and unusual disruption of cognitive flexibility.

History

Publication status

  • Published

Journal

Journal of Alzheimer's Disease

ISSN

1387-2877

Publisher

IOS Press

Issue

3

Volume

27

Page range

477-482

Department affiliated with

  • Business and Management Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2013-11-22

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