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Association of DISC1 and TSNAX genes and affective disorders in the depression case–control (DeCC) and bipolar affective case–control (BACCS) studies

journal contribution
posted on 2023-06-08, 16:01 authored by A Schosser, Darya GaysinaDarya Gaysina, S Cohen-Woods, P C Chow, L Martucci, N Craddock, A Farmer, A Korszun, C Gunasinghe, J Gray, L Jones, F Tozzi, J Perry, P Muglia, M J Owen, I W Craig, P McGuffin
The gene known as Disrupted-in-Schizophrenia-1, DISC1, was originally discovered in a large family, in which it also co-segregated with bipolar affective disorder (BD) and with major depressive disorder (MDD). The TSNAX (Translin-associated factor X) gene, located immediately upstream of DISC1, has also been suggested as a candidate gene in relation to psychiatric illness, as one transcript resulting from intergenic splicing encodes a novel TSNAX–DISC1 fusion protein. We explored the TSNAX–DISC1 gene region for an association with BD and MDD in a sample of 1984 patients (1469 MDD, 515 BD) and 1376 ethnically matched controls. Eight single nucleotide polymorphisms (SNPs) within the TSNAX–DISC1 region (rs766288, rs3738401, rs2492367, rs6675281, rs12133766, rs1000731, rs7546310 and rs821597) were investigated using the SNPlex Genotyping System. We found a significant allelic and genotypic association of the TSNAX–DISC1 gene region with BD, whereas a haplotypic association was found for both BD and MDD. Therefore, our results suggest an association between the TSNAX–DISC1 region and both forms of affective disorders, and support the hypothesis that a portion of the genotypic overlap between schizophrenia and affective disorders is attributable to this gene.

History

Publication status

  • Published

File Version

  • Published version

Journal

Molecular Psychiatry

ISSN

1359-4184

Publisher

Nature Publishing Group

Issue

8

Volume

15

Page range

844-849

Department affiliated with

  • Psychology Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2013-10-08

First Compliant Deposit (FCD) Date

2013-10-08

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