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The effects of symmetry on the dynamics of antigenic variation
In the studies of dynamics of pathogens and their interactions with a host immune system, an important role is played by the structure of antigenic variants associated with a pathogen. Using the example of a model of antigenic variation in malaria, we show how many of the observed dynamical regimes can be explained in terms of the symmetry of interactions between different antigenic variants. The results of this analysis are quite generic, and have wider implications for understanding the dynamics of immune escape of other parasites, as well as for the dynamics of multi-strain diseases.
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Publication status
- Published
File Version
- Published version
Journal
Journal of Mathematical BiologyISSN
0303-6812Publisher
Springer VerlagExternal DOI
Issue
1-2Volume
66Page range
115-137Department affiliated with
- Mathematics Publications
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- No
Peer reviewed?
- Yes
Legacy Posted Date
2013-09-20First Compliant Deposit (FCD) Date
2013-09-20Usage metrics
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