Green, C. M. (2006) One ring to rule them all? Another cellular responsibility for PCNA. Trends in Molecular Medicine, 12 (10). pp. 455-458. ISSN 1471-4914

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Abstract

To prevent duplication or loss of genomic regions during DNA replication, it is essential that the entire genome is copied precisely once every S phase. Cells achieve this by mutually exclusive regulation of origin firing and licensing. A crucial protein that is involved in origin licensing is chromatin licensing and DNA replication factor 1 (CDT1) and, therefore, activity of this protein must be strictly controlled. Four recent articles have demonstrated that proliferating cell nuclear antigen (PCNA), an essential sliding clamp used in replication and DNA repair, has a crucial role in this process by mediating the proteasomal degradation of CDT1.

Item Type:	Article
Subjects:	R Medicine > R Medicine (General) Q Science > QD Chemistry Q Science > QH Natural history > QH0301 Biology
Depositing User:	Catherine Mary Green
Date Deposited:	14 Nov 2006
Last Modified:	08 Oct 2019 11:49
URI:	http://sro.sussex.ac.uk/id/eprint/461
Google Scholar:	3 Citations

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