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Koning, Fransje A, Badhan, Anjna, Shaw, Simon, Fisher, Martin, Mbisa, Jean L and Cane, Patricia A (2013) Dynamics of HIV type 1 recombination following superinfection. AIDS Research and Human Retroviruses, 29 (6). pp. 963-970. ISSN 0889-2229
Full text not available from this repository.Abstract
There are currently few detailed studies describing HIV-1 recombination events or the potential impact of recombination on drug resistance. We describe here the viral recombination dynamics in a drug-naive patient initially infected with a circulating recombinant form 19 (CRF19) virus containing transmitted drug resistance mutations followed by superinfection with "wild-type" subtype B virus. Single genome analysis showed replacement of the primary CRF19 virus by recombinants of the CRF19 virus and the superinfecting subtype B virus. The CRF19/B recombinant virus dominating after superinfection had lost drug resistance mutations and at no time was the superinfecting subtype B variant found to be dominant in blood plasma. Furthermore, the detection of recombinant viruses in seminal plasma indicates the potential for onward transmission of these strains.
| Item Type: | Article |
|---|---|
| Schools and Departments: | Brighton and Sussex Medical School > Brighton and Sussex Medical School |
| Subjects: | R Medicine > RC Internal medicine > RC0109 Infectious and parasitic diseases |
| Depositing User: | Ellen Thomas |
| Date Deposited: | 19 Aug 2013 14:52 |
| Last Modified: | 19 Aug 2013 14:52 |
| URI: | http://sro.sussex.ac.uk/id/eprint/45861 |