Dynamics of HIV type 1 recombination following superinfection

Koning, Fransje A, Badhan, Anjna, Shaw, Simon, Fisher, Martin, Mbisa, Jean L and Cane, Patricia A (2013) Dynamics of HIV type 1 recombination following superinfection. AIDS Research and Human Retroviruses, 29 (6). pp. 963-970. ISSN 0889-2229

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There are currently few detailed studies describing HIV-1 recombination events or the potential impact of recombination on drug resistance. We describe here the viral recombination dynamics in a drug-naive patient initially infected with a circulating recombinant form 19 (CRF19) virus containing transmitted drug resistance mutations followed by superinfection with "wild-type" subtype B virus. Single genome analysis showed replacement of the primary CRF19 virus by recombinants of the CRF19 virus and the superinfecting subtype B virus. The CRF19/B recombinant virus dominating after superinfection had lost drug resistance mutations and at no time was the superinfecting subtype B variant found to be dominant in blood plasma. Furthermore, the detection of recombinant viruses in seminal plasma indicates the potential for onward transmission of these strains.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Brighton and Sussex Medical School
Subjects: R Medicine > RC Internal medicine > RC0109 Infectious and parasitic diseases
Depositing User: Ellen Thomas
Date Deposited: 19 Aug 2013 14:52
Last Modified: 19 Aug 2013 14:52
URI: http://sro.sussex.ac.uk/id/eprint/45861
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