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Clinical validity of plasma and urinary desmosine as biomarkers for chronic obstructive pulmonary diseasa

journal contribution
posted on 2023-06-08, 14:59 authored by Jeffrey T-J Huang, Rekha Chaudhuri, Osama Albarbarawi, Alun Barton, Christal Grierson, Petra Rauchhaus, Christopher J Weir, Martina Messow, Nicola Stevens, Charles McSharry, Giora Feuerstein, Somnath MukhopadhyaySomnath Mukhopadhyay, Jeffrey Brady, Colin N A Palmer, Douglas Miller, Neil C Thomson
Background Although an increased concentration of degraded elastin products in patients with chronic obstructive pulmonary disease (COPD) has been reported for many years, its clinical validity and utility remain uncertain due to technical difficulties, small study groups and the unknown relationship between exacerbation and elastin degradation. The objectives of this study were to determine the validity of urinary and blood total desmosine/isodesmosine in patients with COPD and asthma and to evaluate their relationship to exacerbation status and lung function.

History

Publication status

  • Published

File Version

  • Published version

Journal

Thorax

ISSN

1468-3296

Publisher

British Thoracic Society (BTS)

Issue

6

Volume

67

Page range

502-508

Department affiliated with

  • Clinical and Experimental Medicine Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2013-05-21

First Compliant Deposit (FCD) Date

2013-05-21

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