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Clinical validity of plasma and urinary desmosine as biomarkers for chronic obstructive pulmonary diseasa
journal contribution
posted on 2023-06-08, 14:59 authored by Jeffrey T-J Huang, Rekha Chaudhuri, Osama Albarbarawi, Alun Barton, Christal Grierson, Petra Rauchhaus, Christopher J Weir, Martina Messow, Nicola Stevens, Charles McSharry, Giora Feuerstein, Somnath MukhopadhyaySomnath Mukhopadhyay, Jeffrey Brady, Colin N A Palmer, Douglas Miller, Neil C ThomsonBackground Although an increased concentration of degraded elastin products in patients with chronic obstructive pulmonary disease (COPD) has been reported for many years, its clinical validity and utility remain uncertain due to technical difficulties, small study groups and the unknown relationship between exacerbation and elastin degradation. The objectives of this study were to determine the validity of urinary and blood total desmosine/isodesmosine in patients with COPD and asthma and to evaluate their relationship to exacerbation status and lung function.
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Publication status
- Published
File Version
- Published version
Journal
ThoraxISSN
1468-3296Publisher
British Thoracic Society (BTS)External DOI
Issue
6Volume
67Page range
502-508Department affiliated with
- Clinical and Experimental Medicine Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2013-05-21First Compliant Deposit (FCD) Date
2013-05-21Usage metrics
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