File(s) not publicly available
Dynamic properties, interactions and adaptive modifications of vestibulo-ocular reflex and optokinetic response in mice
journal contribution
posted on 2023-06-08, 14:35 authored by M Iwashita, R Kanai, K Funabiki, K Matsuda, T HiranoDynamic properties of horizontal vestibulo-ocular reflex (VOR) and optokinetic response (OKR) were studied in mice. The VOR was examined in the dark (VORD), in the light (VORL) and in the condition in which most of the visual field moves synchronously with the head motion (VORF). A mouse and/or a surrounding screen with vertical stripes was rotated sinusoidally, and the gain and phase of eye movements were measured in wide dynamic stimulation ranges. The working conditions of VOR and OKR were supplementary; OKR worked at low speeds of head turn and VOR at high speeds. Examination of VORL and VORF revealed non-linear interaction of VOR and OKR. The continuous sinusoidal head oscillation coupled with the in-phase or the out-of-phase oscillation of the surrounding screen, decreased or increased the VORD gain, and increased or decreased the VORD phase lead, respectively. Continuous oscillation of the surrounding screen increased the OKR gain and decreased the phase delay. These changes of VOR and OKR work to reduce the retinal slip. The present study provides fundamental information concerning the dynamic properties of VOR and OKR and the nature of their adaptive modifications in mice, which have been extensively used in genetic manipulation recently.
History
Publication status
- Published
Journal
Neuroscience ResearchISSN
0168-0102Publisher
ElsevierExternal DOI
Issue
3Volume
39Page range
299-311Department affiliated with
- Psychology Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2013-03-11Usage metrics
Categories
No categories selectedKeywords
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC