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Transcranial alternating current stimulation (tACS) modulates cortical excitability as assessed by TMS-induced phosphene thresholds

journal contribution
posted on 2023-06-08, 14:34 authored by Ryota Kanai, Walter Paulus, Vincent Walsh
OBJECTIVE Recent developments in transcranial alternating current stimulation (tACS) provide a powerful approach to establish the functional roles of neuronal oscillatory activities in the human brain. Here, we investigated whether tACS can reach and modulate the excitability of the visual cortex in a frequency-dependent manner. METHODS We measured the cortical excitability of the visual cortex using single pulse transcranial magnetic stimulation (TMS) while delivering tACS to the occipital region at different frequencies (5, 10, 20 and 40 Hz). RESULTS We found that tACS at 20 Hz decreased TMS-phosphene threshold (i.e., increased the excitability of the visual cortex) during the stimulation, whereas other frequencies did not affect TMS-phosphene thresholds. CONCLUSIONS Our findings demonstrate direct interactions of tACS with the visual cortex in a frequency-dependent manner. SIGNIFICANCE Our present work provides further demonstration of the potential of tACS as a method to selectively modulate the excitability of the visual cortex.

History

Publication status

  • Published

Journal

Clinical Neurophysiology

ISSN

1388-2457

Publisher

Elsevier

Issue

9

Volume

121

Page range

1551-1554

Department affiliated with

  • Psychology Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2013-03-11

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