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Yin, Bu, Savic, Velibor and Bassing, Craig H (2007) ATM prevents unattended DNA double strand breaks on site and in generations to come. Cancer Biology and Therapy, 6 (12). pp. 1837-1839. ISSN 1538-4047
Full text not available from this repository.Abstract
Ataxia telangiectasia (A-T) is a disorder characterized by cerebellar degeneration, immunodeficiency, genomic instability and genetic predisposition to lymphoid malignancies with translocations involving antigen receptor loci. The Ataxia Telangiectasia Mutated gene encodes the ATM kinase, a central transducer of DNA damage signals. Until recently, the etiology of the lymphoid phenotype in A-T patients and the mechanisms by which ATM ensures normal repair of DNA double strand break (DSB) intermediates during antigen receptor diversification reactions remained poorly understood. Last year, Bredemeyer et al. (Nature 2006; 442:466-70) demonstrated that ATM stabilizes chromosomal V(D)J recombination DSB intermediates, facilitates DNA end joining and prevents broken DNA ends from participating in chromosome deletions, inversions and translocations. A more recent study by Callen et al. (Cell 2007; 130:63-75) highlighted the importance of ATM-mediated checkpoints in blocking the long-term persistence and transmission of un-repaired DSBs in developing lymphocytes. Collectively, these results have provided complementary mechanistic insights into ATM functions in V(D)J recombination that can account for the lymphoid tumor-prone phenotype associated with A-T
| Item Type: | Article |
|---|---|
| Schools and Departments: | Brighton and Sussex Medical School > Clinical and Experimental Medicine |
| Subjects: | Q Science > QH Natural history > QH0301 Biology Q Science > QH Natural history > QH0301 Biology > QH0426 Genetics > QH0460 Mutations R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology Including cancer and carcinogens |
| Depositing User: | Velibor Savic |
| Date Deposited: | 11 Feb 2013 13:55 |
| Last Modified: | 14 May 2015 09:32 |
| URI: | http://sro.sussex.ac.uk/id/eprint/43586 |