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Common variable immunodeficiency: an update on etiology and management
journal contribution
posted on 2023-06-08, 13:57 authored by Patrick F K Yong, Michael TarziMichael Tarzi, Ignatius Chua, Bodo Grimbacher, Ronnie CheeCommon variable immunodeficiency (CVID) represents a heterogeneous group of primary antibody deficiency disorders characterized by recurrent infection and by inflammatory, granulomatous, and autoimmune complications. Recently, there have been significant advances in understanding the pathogenesis of the disease, with five genetic mutations identified in patients who have a CVID phenotype. Clinical care also has progressed with refinements in treatment and the development of classification schemes for prognostic and research purposes. Significant delays in diagnosis remain, however. It is likely that more genetic defects will be identified in the future, further shrinking the pool of patients who have CVID of unknown cause
History
Publication status
- Published
Journal
Immunology and Allergy Clinics of North AmericaISSN
0889-8561Publisher
ElsevierExternal DOI
Issue
2Volume
28Page range
367-386Department affiliated with
- Clinical and Experimental Medicine Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2012-11-30Usage metrics
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