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Common variable immunodeficiency: an update on etiology and management

journal contribution
posted on 2023-06-08, 13:57 authored by Patrick F K Yong, Michael TarziMichael Tarzi, Ignatius Chua, Bodo Grimbacher, Ronnie Chee
Common variable immunodeficiency (CVID) represents a heterogeneous group of primary antibody deficiency disorders characterized by recurrent infection and by inflammatory, granulomatous, and autoimmune complications. Recently, there have been significant advances in understanding the pathogenesis of the disease, with five genetic mutations identified in patients who have a CVID phenotype. Clinical care also has progressed with refinements in treatment and the development of classification schemes for prognostic and research purposes. Significant delays in diagnosis remain, however. It is likely that more genetic defects will be identified in the future, further shrinking the pool of patients who have CVID of unknown cause

History

Publication status

  • Published

Journal

Immunology and Allergy Clinics of North America

ISSN

0889-8561

Publisher

Elsevier

Issue

2

Volume

28

Page range

367-386

Department affiliated with

  • Clinical and Experimental Medicine Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-11-30

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