Tara, Fatemeh, Maamouri, Gholamali, Rayman, Margaret P, Ghayour-Mobarhan, Majid, Sahebkar, Amirhossein, Yazarlu, Omid, Ouladan, Shaida, Tavallaie, Shima, Azimi-Nezhad, Mohsen, Shakeri, Mohammad T, Boskabadi, Hasan, Oladi, Mohammadreza, Sangani, Maryam Teimoori, Razavi, Behjat S and Ferns, Gordon (2010) Selenium supplementation and the incidence of preeclampsia in pregnant Iranian women: a randomized, double-blind, placebo-controlled pilot trial. Taiwanese Journal of Obstetrics and Gynecology, 49 (2). pp. 181-187. ISSN 1875-6263

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Abstract

OBJECTIVE

Recent studies have reported that antioxidant status, including serum selenium concentrations, is altered in women who develop preeclampsia. We wished to examine the effects of selenium supplementation in the prevention of preeclampsia in high-risk pregnant women.

DESIGN

We carried out a randomized, double-blind, placebo-controlled pilot trial. A total of 166 primigravid pregnant women, who were in the first trimester of pregnancy, were randomized to receive 100 microg of selenium (n = 83; dropouts, n = 22) or a placebo (n = 83; dropouts, n = 19) per day until delivery. The incidence of preeclampsia, serum selenium concentrations, lipid profile and high-sensitivity C-reactive protein status were evaluated at baseline and at the end of the study.

RESULTS

Supplementation with selenium was not associated with any reported major side effects and was associated with a significant increase in mean serum selenium concentrations at term (p < 0.001). In contrast, mean serum selenium concentrations remained unchanged in the control group (p = 0.63). The incidence of preeclampsia was lower in the selenium group (n = 0) than in the control group (n = 3), although this was not statistically significant (p > 0.05). After treatment, systolic and diastolic blood pressure, serum total cholesterol, triglycerides, low-density and high-density lipoprotein cholesterol, and high-sensitivity C-reactive protein were significantly increased in both groups compared with pretreatment levels (p < 0.05).

CONCLUSION

Our findings indicate that selenium supplementation in pregnant women may be associated with a lower frequency of preeclampsia

Item Type:	Article
Schools and Departments:	Brighton and Sussex Medical School > Division of Medical Education
Subjects:	R Medicine > R Medicine (General) > R735 Medical education
Depositing User:	Gordon Ferns
Date Deposited:	19 Nov 2012 06:54
Last Modified:	19 Nov 2012 06:54
URI:	http://sro.sussex.ac.uk/id/eprint/42659

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