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Association between angiotensin II type 1 receptor gene polymorphism and metabolic syndrome in a young female Iranian population

journal contribution
posted on 2023-06-08, 13:46 authored by Jamshid Alavi-Shahri, Javad Behravan, Mitra Hassany, Farnoosh Tatari, Jamal Kasaian, Rashin Ganjali, Shima Tavallaie, Somayeh Sabouri, Amirhossein Sahebkar, Mohammadreza Oladi, Naghmeh Mirhosseini, Mohammad T Shakeri, Shideh Montaser-Kouhsari, Shahireh Omidvar Tehrani, Majid Ghayour-Mobarhan, Sophie Visvikis-Siest, Gordon FernsGordon Ferns
BACKGROUND AND AIMS The overall prevalence of obesity and metabolic syndrome (MetS) is increasing among children and adolescents and can predispose to type II diabetes mellitus and cardiovascular disease. There are reported associations between an angiotensin II type I receptor gene polymorphism (AT(1)R/A1166C) with hypertension, myocardial infarction, insulin resistance and cardiovascular disease risk. In the present study, we aimed to investigate whether the AT(1)R/A1166C polymorphism was associated with MetS among adolescent Iranian girls. METHODS A total of 350 adolescent girls aged 15-17 years from high schools and different educational zones of Mashhad city participated in this population-based, genetic association study. Of these individuals, 101 patients had MetS (defined by the NCEP-ATP III criteria); the remaining 249 age-matched girls were considered as the control group. All subjects were genotyped for the AT(1)R/A1166C polymorphism using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. RESULTS Frequencies of the AA, AC and CC genotypes were 164 (65.9%), 80 (32.1%) and 5 (2.0%) in the control group and 79 (78.2%), 20 (19.8%) and 2 (2.0%) in patients, which were not consistent with the Hardy-Weinberg equilibrium (p <0.05 and p <0.001, respectively). Frequency of the AT(1)R C allele was found to be significantly lower in patients compared with controls (p <0.05). CONCLUSIONS Our findings suggested that the 1166C allele of AT(1)R gene may be associated with a decreased risk of MetS in adolescent Iranian females

History

Publication status

  • Published

Journal

Archives of Medical Research

ISSN

0188-4409

Publisher

Elsevier

Issue

5

Volume

41

Page range

343-349

Department affiliated with

  • Division of Medical Education Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-11-19

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