Sahebkar, Amirhossein, Pourghadamyari, Hossein, Moohebati, Mohsen, Parizadeh, Seyed Mohammad Reza, Falsoleiman, Homa, Dehghani, Mashallah, Fazlinezhad, Afsoon, Akhlaghi, Saeed, Tavallaie, Shima, Paydar, Roghayeh, Ghayour-Mobarhan, Majid and Ferns, Gordon A (2011) A cross-sectional study of the association between heat shock protein 27 antibody titers, pro-oxidant-antioxidant balance and metabolic syndrome in patients with angiographically-defined coronary artery disease. Clinical Biochemistry, 44 (17-18). pp. 1390-1395. ISSN 0009-9120
Full text not available from this repository.Abstract
OBJECTIVE
To investigate the association between serum antibody titers to Hsp27 (anti-Hsp27) and pro-oxidant-antioxidant balance (PAB) in patients with angiographically-defined coronary artery disease (CAD) with or without the metabolic syndrome (MS).
DESIGN
Subjects (n=243) were classified into MS+ (n=161) and MS- (n=82) subgroups, based on the AHA/NHBLI criteria.
RESULTS
Serum anti-Hsp27 titers were found to be significantly higher in the MS+ vs. MS- group. However, no significant difference was observed in serum PAB values. When assessed for individual components of MS, increased serum anti-Hsp27 was found to be higher in subgroups with elevated triglycerides, elevated blood pressure and reduced high-density lipoprotein cholesterol (HDL-C). Subgroups of patients with elevated triglycerides had higher PAB values. HDL-C was the only significant predictor of anti-Hsp27 in the population as a whole.
CONCLUSION
The evidence from this investigation indicates the presence of elevated anti-Hsp27 in patients with concurrent CAD and MS compared to those with CAD alone.
Item Type: | Article |
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Schools and Departments: | Brighton and Sussex Medical School > Division of Medical Education |
Subjects: | R Medicine > R Medicine (General) > R735 Medical education |
Related URLs: | |
Depositing User: | Gordon Ferns |
Date Deposited: | 16 Nov 2012 16:51 |
Last Modified: | 02 Jun 2021 09:26 |
URI: | http://sro.sussex.ac.uk/id/eprint/42642 |