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Increased serum heat shock protein 27 antibody titers and prooxidant-antioxidant balance in patients with beta-thalassemia major
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posted on 2023-06-08, 13:45 authored by E Ghahremanlu, A Banihashem, H Saber, S Tavallaie, N Mirhosseini, M Ghayour-Mobarhan, Gordon FernsGordon FernsObjective: Determination of the serum heat shock protein 27 (Hsp27) antibody titers and prooxidant-antioxidant balance (PAB) in patients with thalassemia as markers of cell and oxidative stress, respectively. Methods: Serum PAB and anti-Hsp27 antibody titers were measured in 140 patients with thalassemia major and 140 sex- and age-matched healthy volunteers. Results: A significantly higher serum PAB value was observed in patients in comparison to controls. In the patient group, anti-Hsp27 antibody titers were significantly higher than for the control group (p < 0.001). We found a weak negative correlation between anti-Hsp27 antibody concentrations and the PAB (p = 0.03), but these values were not correlated with serum superoxide dismutase activity in the thalassemic patients. Conclusions: Increased levels of serum PAB and Hsp27 antibodies may be involved in the pathological consequences of ß-thalassemia major and may contribute to the development of endothelial injury.
History
Publication status
- Published
Journal
Acta HaematologicaISSN
0001-5792Publisher
Karger PublishersPublisher URL
External DOI
Issue
1Volume
129Page range
1-9Department affiliated with
- Division of Medical Education Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2012-11-16Usage metrics
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