Manser, Catherine, Stevenson, Alison, Banner, Steven, Davies, Jennifer, Tudor, Elizabeth L, Ono, Yoshitaka, Leigh, P Nigel, McLoughlin, Declan M, Shaw, Christopher E and Miller, Christopher C J (2008) Deregulation of PKN1 activity disrupts neurofilament organisation and axonal transport. FEBS letters, 582 (15). pp. 2303-8. ISSN 0014-5793
Full text not available from this repository.Abstract
Neurofilaments are synthesised in neuronal cell bodies and then transported through axons. Damage to neurofilament transport is seen in amyotrophic lateral sclerosis (ALS). Here, we show that PKN1, a neurofilament head-rod domain kinase is cleaved and activated in SOD1G93A transgenic mice that are a model of ALS. Moreover, we demonstrate that glutamate, a proposed toxic mechanism in ALS leads to caspase cleavage and disruption of PKN1 in neurons. Finally, we demonstrate that a cleaved form of PKN1 but not wild-type PKN1 disrupts neurofilament organisation and axonal transport. Thus, deregulation of PKN1 may contribute to the pathogenic process in ALS
Item Type: | Article |
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Schools and Departments: | Brighton and Sussex Medical School > Clinical and Experimental Medicine Brighton and Sussex Medical School > Neuroscience |
Subjects: | R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry > RC0346 Neurology. Diseases of the nervous system Including speech disorders |
Depositing User: | Patricia Butler |
Date Deposited: | 14 Nov 2012 17:50 |
Last Modified: | 25 Sep 2017 13:57 |
URI: | http://sro.sussex.ac.uk/id/eprint/42520 |