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Deletion variant of alpha2b-adrenergic receptor gene moderates the effect of COMT val(158)met polymorphism on episodic memory performance

journal contribution
posted on 2023-06-08, 13:39 authored by Ayana A Gibbs, Kris H Naudts, Ruben T Azevedo, Anthony S David
The COMT val(158) variant has been associated with impaired cognitive function compared to the met(158) variant yet gene-gene interactions are not well described. In this study we demonstrate an interaction between this COMT polymorphism and a deletion variant of ADRA2B, the gene encoding the alpha2b-adrenergic receptor on episodic memory performance. Specifically, carriage of the ADRA2B deletion abolished the relative memory impairment in homozygous COMT val(158) carriers compared to met(158) carriers

History

Publication status

  • Published

Journal

European Neuropsychopharmacology

ISSN

0924-977X

Publisher

Elsevier

Issue

4

Volume

20

Page range

272-275

Department affiliated with

  • Clinical and Experimental Medicine Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-11-14

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