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Gibbs, Ayana A, Naudts, Kris H, Azevedo, Ruben T and David, Anthony S (2010) Deletion variant of alpha2b-adrenergic receptor gene moderates the effect of COMT val(158)met polymorphism on episodic memory performance. European Neuropsychopharmacology, 20 (4). pp. 272-275. ISSN 0924-977X
Full text not available from this repository.Abstract
The COMT val(158) variant has been associated with impaired cognitive function compared to the met(158) variant yet gene-gene interactions are not well described. In this study we demonstrate an interaction between this COMT polymorphism and a deletion variant of ADRA2B, the gene encoding the alpha2b-adrenergic receptor on episodic memory performance. Specifically, carriage of the ADRA2B deletion abolished the relative memory impairment in homozygous COMT val(158) carriers compared to met(158) carriers
| Item Type: | Article |
|---|---|
| Keywords: | CATECHOL-O-METHYLTRANSFERASE; PREFRONTAL CORTEX; MODULATION; DOPAMINE; AMYGDALA; COGNITION; GENOTYPE; STIMULI; PROTEIN; STRESS |
| Schools and Departments: | Brighton and Sussex Medical School > Clinical and Experimental Medicine |
| Subjects: | R Medicine > R Medicine (General) > R895 Medical physics. Medical radiology. Nuclear medicine R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry > RC0346 Neurology. Diseases of the nervous system Including speech disorders |
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| Depositing User: | Hazelle Woodhurst |
| Date Deposited: | 14 Nov 2012 14:46 |
| Last Modified: | 11 Jun 2013 09:34 |
| URI: | http://sro.sussex.ac.uk/id/eprint/42455 |