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1,25-Dihydroxyvitamin D3 upregulates functional CXCR4 human immunodeficiency virus type 1 coreceptors in U937 minus clones: NF-kappaB-independent enhancement of viral replication
journal contribution
posted on 2023-06-08, 13:34 authored by Priscilla Biswas, Manuela MengozziManuela Mengozzi, Barbara Mantelli, Fanny Delfanti, Andrea Brambilla, Elisa Vicenzi, Guido PoliU937 cell clones which sustain efficient or poor replication of human immunodeficiency virus type 1 (HIV-1) (referred to herein as plus clones and minus clones, respectively) have been previously described. 1,25-Dihydroxyvitamin D3 (vitamin D3) potently induced HIV-1 replication and proviral DNA accumulation in minus clones but not in plus clones. Vitamin D3 did not induce NF-kappaB activation but selectively upregulated CXCR4 expression in minus clones. The CXCR4 ligand stromal-cell derived factor-1 induced Ca2+ fluxes and inhibited both constitutive and vitamin D3-enhanced HIV replication in minus clones.
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Publication status
- Published
Journal
Journal of VirologyISSN
0022-538XPublisher
American Society for MicrobiologyIssue
10Volume
72Page range
8380-8383Department affiliated with
- Clinical and Experimental Medicine Publications
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- No
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- Yes
Legacy Posted Date
2012-11-14Usage metrics
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