The sex ratio in amyotrophic lateral sclerosis: A population based study

Manjaly, Zita R, Scott, Kirsten M, Abhinav, Kumar, Wijesekera, Lokesh, Ganesalingam, Jeban, Goldstein, Laura H, Janssen, Anna, Dougherty, Andrew, Willey, Emma, Stanton, Biba R, Turner, Martin R, Ampong, Mary-Ann, Sakel, Mohammed, Orrell, Richard W, Howard, Robin, Shaw, Chris E, Leigh, Nigel and Al-Chalabi, Ammar (2010) The sex ratio in amyotrophic lateral sclerosis: A population based study. Amyotrophic Lateral Sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases, 11 (5). pp. 439-42. ISSN 1471-180X

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Replicable risk factors for ALS include increasing age, family history and being male. The male: female ratio has been reported as being between 1 and 3. We tested the hypothesis that the sex ratio changes with age in a population register covering the south-east of England. The sex ratio before and after the age of 51 years was compared using a Z-test for proportions. Kendall's tau was used to assess the relationship between age group and sex ratio using incidence and prevalence data. Publicly available data from Italian and Irish population registers were compared with results. There was a significant difference in the proportion of females with ALS between those in the younger group (30.11%) and those in the older group (43.66%) (p = 0.013). The adjusted male: female ratio dropped from 2.5 in the younger group to 1.4 in the older group using prevalence data (Kendall's tau = -0.73, p = 0.039). Similar ratios were found in the Italian but not the Irish registry. We concluded that sex ratios in ALS may change with age. Over-representation of younger patients in clinic registers may explain the variation in sex ratios between studies. Menopause may also play a role

Item Type: Article
Keywords: Amyotrophic lateral sclerosis, epidemiology, testosterone, oestrogen, menopause
Schools and Departments: Brighton and Sussex Medical School > Clinical and Experimental Medicine
Brighton and Sussex Medical School > Neuroscience
Subjects: R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry > RC0346 Neurology. Diseases of the nervous system Including speech disorders
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Depositing User: Patricia Butler
Date Deposited: 14 Nov 2012 09:15
Last Modified: 25 Jan 2018 11:00
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