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Serum inflammatory and immune marker response after bare-metal or drug-eluting stent implantation following percutaneous coronary intervention
journal contribution
posted on 2023-06-08, 13:33 authored by Mohsen Moohebati, Homa Falsoleiman, Mashalla Dehghani, Afsoon Fazlinezhad, Mehdi Hassanzadeh Daloee, Habib Esmaeili, Seyyed Mohammad Reza Parizadeh, Shima Tavallaie, Amir Ali Rahsepar, Roghayeh Paydar, Seyyed Mohammad Reza Kazemi-Bajestani, Hossein Pourghadam-Yari, Mina Akbari Rad, Talat Zoghdar-Moghadam, Majid Ghayour-Mobarhan, Gordon FernsGordon FernsWe assessed the changes in serum antiheat shock protein (HSP)-27 antibody and high-sensitivity C-reactive protein (hsCRP) levels, following the placement of a drug-eluting stent (DES) or bare-metal stent (BMS) in patients with stable coronary artery disease. Either a BMS or DES was implanted in 137 patients (82 BMS; 55 DES). Anti-HSP27 and hsCRP levels were measured 24 hours before and 24 hours after stenting. Median hsCRP serum levels increased significantly to 60.78 (10.13-84.87) and 77.80 (50.00-84.84) mg/L for BMS and DES groups (P = .006 and P = .000, respectively); this increase did not differ significantly between the 2 groups. Median anti-HSP27 antibody levels decreased to 0.26 (0.17-0.49) and 0.21 (0.16-0.29) absorbency units in BMS and DES groups (P = .045 and P = < 0.001, respectively). The changes in anti-HSP27 antibody titers were significant between the 2 groups (P = .015). Bare-metal stent and DES differ in stimulation of immune rather than inflammatory responses. Less stent restenosis after DES compared with BMS implantation could, in part, be attributed to differences in immune responses.
History
Publication status
- Published
Journal
AngiologyISSN
1940-1574Publisher
SageExternal DOI
Issue
2Volume
62Page range
184-190Department affiliated with
- Division of Medical Education Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2012-11-19Usage metrics
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