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HDL-cholesterol modulation and its impact on the management of cardiovascular risk
journal contribution
posted on 2023-06-08, 13:25 authored by Gordon FernsGordon Ferns, Vuyolethu KetiThere is strong epidemiological evidence that HDL-cholesterol (HDL-C) is an independent cardiovascular risk factor. A low HDL-C is a common finding in the general population, and is a feature of metabolic syndrome, the prevalence of which is increasing globally. The importance of HDL-C as a coronary risk factor is generally accepted, and has been incorporated into most of the commonly applied risk engines. There are several causes of a low HDL-C, including rare genetic abnormalities, and more common conditions associated with lifestyle and drug therapy. Not all of these are associated with an increased risk of coronary disease. A better understanding of HDL metabolism and the mechanisms by which it may exert its protective effects has revealed why this may be the case. New therapeutic targets have also been identified that may allow HDL-C to be raised in patients with low levels. However, good clinical endpoint studies are still required to enable the setting of absolute target values for HDL-C in patients at high cardiovascular risk
History
Publication status
- Published
Journal
Annals of Clinical BiochemistryISSN
1758-1001Publisher
Royal Society of Medicine PressPublisher URL
External DOI
Issue
2Volume
45Page range
122-128Department affiliated with
- Clinical and Experimental Medicine Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2012-11-02Usage metrics
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