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Khaleeli, Zhaleh, Altmann, Daniel R, Cercignani, Mara, Ciccarelli, Olga, Miller, David H and Thompson, Alan J (2008) Magnetization transfer ratio in gray matter: a potential surrogate marker for progression in early primary progressive multiple sclerosis. Archives of Neurology, 65 (11). pp. 1454-1459. ISSN 1531-8249
Full text not available from this repository.Abstract
BACKGROUND
Magnetization transfer imaging has the potential to provide a surrogate marker for progression in primary progressive multiple sclerosis (PPMS).
OBJECTIVES
To investigate whether brain magnetization transfer imaging, T2 lesion load, and atrophy changes over 3 years reflect concurrent clinical changes, and which baseline imaging measure best predicts progression over 3 years in early PPMS.
DESIGN
Prospective study.
SETTING
National Hospital for Neurology and Neurosurgery and the Institute of Neurology, London, England.
PATIENTS
Forty-seven patients with PPMS (of whom 43 completed the study) and 18 control subjects.
INTERVENTIONS
Brain magnetization transfer imaging (including T2-weighted images) and volume sequences every 6 months for 3 years.
MAIN OUTCOME MEASURES
Changes in Expanded Disability Status Scale (EDSS) score and associations with rate of change in imaging variables.
RESULTS
More rapid decline in gray matter mean and peak location magnetization transfer ratio and T2 lesion load increase were associated with greater rates of progression on the EDSS. Baseline gray matter peak height magnetization transfer ratio best predicted progression over 3 years.
CONCLUSION
Gray matter magnetization transfer ratio meets many of the criteria for a surrogate marker of progression in early PPMS.
| Item Type: | Article |
|---|---|
| Schools and Departments: | Brighton and Sussex Medical School > Clinical and Experimental Medicine Brighton and Sussex Medical School > Neuroscience |
| Subjects: | R Medicine > R Medicine (General) > R895 Medical physics. Medical radiology. Nuclear medicine R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry > RC0346 Neurology. Diseases of the nervous system Including speech disorders |
| Depositing User: | Patricia Butler |
| Date Deposited: | 01 Nov 2012 15:28 |
| Last Modified: | 26 Sep 2017 13:21 |
| URI: | http://sro.sussex.ac.uk/id/eprint/41613 |