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Probiotics for the prevention and treatment of Clostridium difficile in older patients
journal contribution
posted on 2023-06-08, 12:38 authored by Jasmin Islam, J Cohen, Chakravarthi RajkumarChakravarthi Rajkumar, Martin LlewelynMartin LlewelynClostridium difficile infection (CDI) is the leading cause of nosocomial diarrhoea in older people, causing substantial morbidity and mortality. The fact that CDI is almost exclusively a disease of older people and the debilitated indicates that patient susceptibility is a major determinant of who gets CDI. It would help efforts to combat this disease if we better understood and could reduce patient susceptibility. In this regard, several strategies are currently under investigation. The use of probiotics for CDI has received particular attention in the medical and lay media. Patients and their carers often ask doctors about them. In this review article, we describe the pathogenesis of CDI before looking at the ageing host in more detail. We discuss how probiotics may work and review the current evidence for their use in CDI.
History
Publication status
- Published
Journal
Age and AgeingISSN
0002-0729Publisher
Oxford University PressPublisher URL
External DOI
Issue
6Volume
41Page range
706-711Department affiliated with
- Clinical and Experimental Medicine Publications
Notes
probiotics, Clostridium difficile, immunesenescence, antibiotic-associated diarrhoea, intestinal microflora, older peopleFull text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2012-10-17Usage metrics
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