de_novo_2012.pdf (530.99 kB)
De novo cryoglobulinaemic mononeuritis multiplex during treatment of chronic hepatitis C infection: a viral effect or induced by pegylated interferon alpha?
journal contribution
posted on 2023-06-08, 12:35 authored by J R Potts, S Atkinson, J A Aram, J Tibble, Kevin DaviesKevin Davies, Sumita VermaSumita VermaCryoglobulinaemic mononeuritis multiplex (MNM) is an extrahepatic manifestation of chronic hepatitis C virus (HCV) infection for which interferon-based antiviral therapy is currently the treatment of choice. Rarely MNM can be associated with HCV treatment though generally in the setting of pre-existing cryoglobulinaemia and detectable HCV viraemia. We report an unusual case of de novo MNM occurring late during the course of pegylated interferon and ribavirin therapy for chronic HCV infection, following a prolonged period of viral suppression. The patient had no evidence of cryoglobulinaemia prior to HCV treatment and undetectable HCV RNA levels at the time of presentation with MNM. The case raises the possibility that MNM could develop as an adverse immunomodulatory effect of pegylated interferon therapy.
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Publication status
- Published
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- Published version
Journal
Case Reports in GastroenterologyISSN
1662–0631Publisher
KargerExternal DOI
Issue
1Volume
6Page range
155-161Department affiliated with
- Clinical and Experimental Medicine Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2012-10-31First Open Access (FOA) Date
2012-10-31First Compliant Deposit (FCD) Date
2012-10-31Usage metrics
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