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De novo cryoglobulinaemic mononeuritis multiplex during treatment of chronic hepatitis C infection: a viral effect or induced by pegylated interferon alpha?

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posted on 2023-06-08, 12:35 authored by J R Potts, S Atkinson, J A Aram, J Tibble, Kevin DaviesKevin Davies, Sumita VermaSumita Verma
Cryoglobulinaemic mononeuritis multiplex (MNM) is an extrahepatic manifestation of chronic hepatitis C virus (HCV) infection for which interferon-based antiviral therapy is currently the treatment of choice. Rarely MNM can be associated with HCV treatment though generally in the setting of pre-existing cryoglobulinaemia and detectable HCV viraemia. We report an unusual case of de novo MNM occurring late during the course of pegylated interferon and ribavirin therapy for chronic HCV infection, following a prolonged period of viral suppression. The patient had no evidence of cryoglobulinaemia prior to HCV treatment and undetectable HCV RNA levels at the time of presentation with MNM. The case raises the possibility that MNM could develop as an adverse immunomodulatory effect of pegylated interferon therapy.

History

Publication status

  • Published

File Version

  • Published version

Journal

Case Reports in Gastroenterology

ISSN

1662–0631

Publisher

Karger

Issue

1

Volume

6

Page range

155-161

Department affiliated with

  • Clinical and Experimental Medicine Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2012-10-31

First Open Access (FOA) Date

2012-10-31

First Compliant Deposit (FCD) Date

2012-10-31

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