Mouse Genetic Approaches to Psychiatric Disorders

King, Sarah L (2010) Mouse Genetic Approaches to Psychiatric Disorders. In: Koob, George F, Le Moal, Michel and Thompson, Richard F (eds.) Encyclopedia of Behavioral Neuroscience. Elsevier Science, London, pp. 280-285. ISBN 9780080453965

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Eighty percent of mammalian genes are expressed at detectable levels in the brain, and it has become a major research endeavor to elucidate the function of individual genes and gene products in behavioral traits and psychiatric disorders. Technologies, developed in the past two decades, to manipulate individual genes, have begun to allow us to ascribe them function in the neurobiological mechanisms that underlie behavior. Two approaches have been taken: a random approach to identify novel genes associated with behavioral phenotypes; and a targeted approach where candidate genes are selectively mutated or expressed in the brain and behavioral function tested. This article explores these different methodologies, and highlights the advantages and disadvantages of the techniques using examples of genes associated with human psychiatric disorders.

Item Type: Book Section
Schools and Departments: School of Psychology > Psychology
Subjects: R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry
Depositing User: Library Cataloguing
Date Deposited: 28 May 2012 08:27
Last Modified: 30 Nov 2012 17:13
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