University of Sussex
Browse

File(s) not publicly available

Investigation of aberrant translational control of c-myc in cell lines derived from patients with multiple myeloma.

journal contribution
posted on 2023-06-08, 11:24 authored by A E Willis, F E Paulin, Michelle WestMichelle West, R L Whitney
In cell lines derived from patients with multiple myeloma (MM) we have found an elevation in the amount of the c-myc protein which is not accompanied by an increase in the level of mRNA or a change in the half-life of the protein. There is a 3.4 fold enhancement in the degree of association of the c-myc message with polysomes. This is not accompanied by an alteration in polysome size or a change in the transit time of the c-myc mRNA on the polysomes thus suggesting that there is in increase in the degree of mobilisation of the c-myc message. Sequencing of the c-myc 5'UTR has revealed the presence of a mutation in all the MM cell lines studied and we demonstrate that this mutation causes altered binding of cellular proteins to this RNA species.

History

Publication status

  • Published

Journal

Current Topics in Microbiology and Immunology

ISSN

0070-217X

Publisher

Springer Verlag

Volume

224

Page range

269-276

Department affiliated with

  • Biochemistry Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-05-03

Usage metrics

    University of Sussex (Publications)

    Categories

    No categories selected

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC