File(s) not publicly available
Regulation of transcription by the Epstein-Barr virus nuclear antigen EBNA 2
journal contribution
posted on 2023-06-08, 11:24 authored by Richard D Palermo, Helen WebbHelen Webb, Andrea Gunnell, Michelle WestMichelle WestThe EBNA 2 (Epstein-Barr nuclear antigen 2) transcription factor is essential for B-cell transformation by the cancer-associated EBV (Epstein-Barr virus) and for the continuous proliferation of infected cells. EBNA 2 activates transcription from the viral Cp (C promoter) during infection to generate the 120 kb transcript that encodes all nuclear antigens required for immortalization by EBV. EBNA 2 contains an acidic activation domain and can interact with a number of general transcription factors and co-activators. It is now becoming clear, however, that the regulation of transcription elongation in addition to initiation by EBNA 2, at least in part through CDK9 (cyclin-dependent kinase 9)-dependent phosphorylation of the RNA polymerase C-terminal domain, is likely to play a crucial role in the mechanism of action of this key viral protein.
History
Publication status
- Published
Journal
Biochemical Society TransactionsISSN
0300-5127Publisher
Portland PressExternal DOI
Issue
4Volume
36Page range
625-8Department affiliated with
- Biochemistry Publications
Research groups affiliated with
- Haematology Research Group Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2012-05-03Usage metrics
Categories
No categories selectedKeywords
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC