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The Application of Intravital Microscopy in Studies of Tumour Microcirculation

journal contribution
posted on 2023-06-08, 11:22 authored by Sarah Jane Lunt, Constantino Carlos Reyes-Aldasoro, Gillian M Tozer, Colin Gray, Stephen J Matcher
To grow and progress, solid tumors develop a vascular network through co-option and angiogenesis that is characterized by multiple structural and functional abnormalities, which negatively influence therapeutic outcome through direct and indirect mechanisms. As such, the morphology and function of tumor blood vessels, plus their response to different treatments, are a vital and active area of biological research. Intravital microscopy (IVM) has played a key role in studies of tumor angiogenesis, and ongoing developments in molecular probes, imaging techniques, and postimage analysis methods have ensured its continued and widespread use. In this review we discuss some of the primary advantages and disadvantages of IVM approaches and describe recent technological advances in optical microscopy (e.g., confocal microscopy, multiphoton microscopy, hyperspectral imaging, and optical coherence tomography) with examples of their application to studies of tumor angiogenesis.

History

Publication status

  • Published

Journal

Journal of Biomedical Optics

ISSN

1083-3668

Publisher

Society of Photo-optical Instrumentation Engineers

Issue

1

Volume

15

Page range

011113

Department affiliated with

  • Engineering and Design Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-04-24

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