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The Application of Intravital Microscopy in Studies of Tumour Microcirculation
journal contribution
posted on 2023-06-08, 11:22 authored by Sarah Jane Lunt, Constantino Carlos Reyes-Aldasoro, Gillian M Tozer, Colin Gray, Stephen J MatcherTo grow and progress, solid tumors develop a vascular network through co-option and angiogenesis that is characterized by multiple structural and functional abnormalities, which negatively influence therapeutic outcome through direct and indirect mechanisms. As such, the morphology and function of tumor blood vessels, plus their response to different treatments, are a vital and active area of biological research. Intravital microscopy (IVM) has played a key role in studies of tumor angiogenesis, and ongoing developments in molecular probes, imaging techniques, and postimage analysis methods have ensured its continued and widespread use. In this review we discuss some of the primary advantages and disadvantages of IVM approaches and describe recent technological advances in optical microscopy (e.g., confocal microscopy, multiphoton microscopy, hyperspectral imaging, and optical coherence tomography) with examples of their application to studies of tumor angiogenesis.
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Publication status
- Published
Journal
Journal of Biomedical OpticsISSN
1083-3668Publisher
Society of Photo-optical Instrumentation EngineersExternal DOI
Issue
1Volume
15Page range
011113Department affiliated with
- Engineering and Design Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2012-04-24Usage metrics
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